Intravenous antibiotics reduce the presence ofAspergillusin adult cystic fibrosis sputum
نویسندگان
چکیده
منابع مشابه
Intravenous antibiotics reduce the presence of Aspergillus in adult cystic fibrosis sputum.
BACKGROUND Pseudomonas aeruginosa and Aspergillus fumigatus frequently co-colonise the airways of patients with cystic fibrosis (CF). This study aimed to assess the impact of short-term administration of intravenous antipseudomonal antibiotics during CF exacerbations on the presence of Aspergillus. METHODS Pre- and post-antibiotic sputum samples from 26 adult patients with CF and chronic Pseu...
متن کاملHome intravenous antibiotics for cystic fibrosis.
BACKGROUND Recurrent endobronchial infection in cystic fibrosis (CF) requires treatment with intravenous antibiotics for several weeks usually in hospital, affecting health costs and quality of life for patients and their families. OBJECTIVES To determine whether home intravenous antibiotic therapy in CF is as effective as inpatient intravenous antibiotic therapy and if it is preferred by ind...
متن کاملIn vivo penetration of antibiotics into sputum in cystic fibrosis.
The control of respiratory tract infections in cystic fibrosis has for many years utilized a wide range of antibiotics. The effect of administering one or more antibiotics to combat an invading organism has, as might be expected, been variable. We have attempted here to determine some of the factors that are responsible for these variations in the hope that a more effective chemotherapeutic con...
متن کاملAntibiotics in Cystic Fibrosis.
IN cystic fibrosis the main problem is the susceptibility of the children to respiratory infection. The clinical course of the untreated case is one of repeated respiratory infections followed by persistent pulmonary sepsis, and later death. Severe attacks may occur in the first weeks or months of life, or less commonly, years may pass with no, or minimal symptoms referable to the chest. Upper ...
متن کاملActivity and Interactions of Liposomal Antibiotics in Presence of Polyanions and Sputum of Patients with Cystic Fibrosis
BACKGROUND To compare the effectiveness of liposomal tobramycin or polymyxin B against Pseudomonas aeruginosa in the Cystic Fibrosis (CF) sputum and its inhibition by common polyanionic components such as DNA, F-actin, lipopolysaccharides (LPS), and lipoteichoic acid (LTA). METHODOLOGY Liposomal formulations were prepared from a mixture of 1,2-Dimyristoyl-sn-Glycero-3-Phosphocholine (DMPC) or...
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ژورنال
عنوان ژورنال: Thorax
سال: 2013
ISSN: 0040-6376,1468-3296
DOI: 10.1136/thoraxjnl-2012-202412